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5-Azacytidine in Translational Oncology: Mechanistic Insi...
2025-10-22
This thought-leadership article explores the mechanistic underpinnings and translational promise of 5-Azacytidine (5-AzaC) as a DNA methyltransferase inhibitor in cancer research. Integrating recent evidence on DNA methylation-driven gene silencing, particularly the hypermethylation-mediated repression of HNF4A in gastric cancer, the article offers actionable guidance for translational researchers. By examining experimental design, competitive agents, and the clinical frontier, it establishes a blueprint for leveraging 5-Azacytidine’s epigenetic modulation in next-generation oncology studies.
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Gap26: Precision Connexin 43 Mimetic Peptide for Immune M...
2025-10-21
Discover how Gap26, a leading connexin 43 mimetic peptide, enables selective gap junction blockade to unravel the Cx43/NF-κB axis in immune polarization and vascular inflammation. This article uniquely explores Gap26’s mechanistic and translational value for researchers investigating neuroprotection and immune modulation.