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PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

  1. Cat.No. Product Name Information
  2. A1877 XAV-939 Tankyrase 1/2 inhibitor
  3. A4164 AZD2461 Novel PARP inhibitor
  4. A4159 PJ34 hydrochloride PARP inhibitor,potent and cell-permeable
  5. A4158 AG-14361 Potent PARP1 inhibitor
  6. A4157 Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered
  7. A4156 Rucaparib (AG-014699,PF-01367338) Potent PARP inhibitor
  8. A4154 Olaparib (AZD2281, Ku-0059436) Potent PARP1/PARP2 inhibitor
  9. A4153 BMN 673 Potent PARP inhibitor
  10. A3002 ABT-888 (Veliparib) Potent PARP inhibitor
  11. A8893 Rucaparib (free base) Potent PARP inhibitor

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