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HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Research Area

  1. Cat.No. Product Name Information
  2. B4890 HPOB HDAC6 inhibitor, potent and selective
  3. B1141 Varenicline Hydrochloride α4β2 nicotinic receptor agonist
  4. A8547 Tubastatin A HCl HDAC6 inhibitor,potent and selective
  5. A4501 Tubacin HDAC6 inhibitor,potent,selective,reversible,cell-permeable
  6. A4105 M344 HDAC inhibitor,potent and cell-permeable
  7. A4103 LAQ824 (NVP-LAQ824,Dacinostat) HDAC inhibitor,potent and novel
  8. A4099 Valproic acid sodium salt (Sodium valproate) HDAC inhibitor
  9. A4098 PCI-24781 (CRA-024781) Pan-HDAC inhibitor
  10. A4096 Belinostat (PXD101) Hydroxamate-type HDAC inhibitor
  11. A4095 Pracinostat (SB939) Pan-HDAC inhibitor

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