Chromatin/Epigenetics
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Products for Chromatin/Epigenetics
- Bromodomain(41)
- Aurora Kinase(35)
- DNA Methyltransferase(14)
- HDAC(66)
- Histone Acetyltransferases(21)
- Histone Demethylases(33)
- Histone Methyltransferase(53)
- HIF(17)
- JAK(49)
- MBT Domains(1)
- PARP(35)
- Pim(13)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(26)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(2)
- PAD(1)
- Cat.No. Product Name Information
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A8181
(-)-JQ1
Stereoisomer of (+)-JQ1, used as negative control
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B7679
(R)-(+)-Etomoxir sodium salt
carnitine palmitoyltransferase I (CPT1) inhibitor
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B7718
(R)-PFI 2 hydrochloride
SETD7 histone lysine methyltransferase inhibitor
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C4834
(S)-PFI-2 (hydrochloride)
Negative control of (R)-PFI 2 hydrochloride
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A4510
1,2,3,4,5,6-Hexabromocyclohexane
JAK2 tyrosine kinase inhibitor
-
C4119
2',3',5'-triacetyl-5-Azacytidine
prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
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B5972
2,4-Pyridinedicarboxylic Acid
Histone LSD inhibitor
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C4445
2-D08
Sumoylation inhibitor
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B5969
2-hexyl-4-Pentynoic Acid
Potent and robust HDACs inhibitor
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A4188
2-Methoxyestradiol (2-MeOE2)
Apoptotic, antiproliferative and antiangiogenic agent
