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Bcl-xL

BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.

Compare Products

  1. Cat.No. Product Name Information
  2. B6163 A-1155463 BCL-XL inhibitor, potent and selective
  3. B6164 A-1331852 BCL-XL inhibitor, potent and selective
  4. A8193 ABT-737 Bcl-2 inhibitor
  5. A3424 Gambogic Acid Caspase activator and apoptosis inducer
  6. A8168 HA14-1 Bcl-2 inhibitor,potent and cell-permeable
  7. A4234 TW-37 Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
  8. A3935 WEHI-539 Bcl-xL inhibitor,potent and selective
  9. A8634 WEHI-539 hydrochloride Bcl-xL inhibitor,high affinity and selective

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